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The AZURE trial is a large multicentre study in which patients with high risk localised breast cancer (without metastasis) are being treated with an intravenous bisphosphonate for a five year period in the adjuvant setting of prevention of recurrence.

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Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and pre-existing dental problems.

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Why you must ask your doctor this question BEFORE you get your next bone scan to avoid being misdiagnosed.

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The foregoing press release contains forward-looking statements that can be identified by the use of forward-looking terminology such as "can", "potential", "expected", "will", "should", similar expressions or express or implied discussions regarding potential future regulatory submissions or approvals with respect to, or future sales of, of Aclasta, Reclast or Zometa.

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Compared with women in the placebo group, the treated women, followed for three years, showed a dramatic decrease in fractures of the spine, the hips, and other bones.

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In general, it was shown to have similar rates of adverse effect as placebo regards cardiovascular incidents, infections, and cancer.

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The initial clearance of a dose of bisphosphonate is rapid, but bone-associated drug must first be released by osteoclast-mediated bone resorption, and removal may extend over a period of weeks to years.

Thus, differences in bone affinity can influence the required dosing of the bisphosphonates and the reversibility of their effects ().

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The Save Our Bones Program is all about drug-free options to treat osteoporosis, and I hope you will take some time to look into the alternatives before choosing to take drugs.

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While density is an indicator of bone metabolism, the main focus of bone health is simply to prevent fractures, and less dense but healthy and renewed bones have better tensile strength than thicker, denser, older bones.

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She is now 58 and reclast has destroyed her teeth and caused necrosis of her jaw.

The patient's physician in consultation with the patient and dental surgeon should be in the best position to consider the benefits versus risks of discontinuation of bisphosphonate therapy.

Search terms and MeSH headings used included mechanism of action combined with the word osteoporosis and each of the following: denosumab, antiresorptive, bisphosphonate, parathyroid hormone and RANK ligand.

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