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At the age of 23 I have been on Hydrea for about two years now due to Essential Thrombocythemia and my platelets count over 2 million. I have tried many different medications for the same purpose but the majority of them caused unbearable side effects. And in spite of the fact that with Hydrea I do have some side effects - fatigue, some muscle pain and easy bruising - I can tolerate them and in addition I get so much better control over my platelets level what is a big change for me. My doctor helps me adjust my dosage and monitors my health condition. He also observes the positive effect Hydrea provides, so I am quite enthusiastic and hopeful. Would recommend Hydrea to other people with similar health condition.

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I would like to share my opinion concerning Hydrea, I hope it would be useful to someone who still haven't found an effective medication or is not sure about the choice. I have been on this medication (1 capsule a day) since the year 2010. I was diagnosed with Myeloperliferative Disease about 7 years ago and since that time I have tried several medications that were supposed to bring my platelets and hemoglobin levels down. And to be honest some of other cancer meds were more or less effective, but I inevitably had to stop the treatment courses and ask my doctor to switch me to another med because of the side effects I couldn't tolerate. Most awful side effects were unbearable pain in my muscles and bones that would keep me awake for many nights on end. I also had nausea and fatigue that would keep me away from my usual duties. I do have a serious illness but I want to stay active and to live my life the way I am used to. And when medications produce some effect but make me suffer and forget about normal life, then these meds are not for me. With Hydrea everything is quite different. I have side effects but they are not that serious for me to stop treatment. Besides the drug is really good for its purpose. So, while looking for something more effective or better to say while waiting for the pharmacists to create a new med, I am more than ok with Hydrea.

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Hydroxyurea in the Treatment of HIV Infection.

People with sickle cell disease can develop cognitive (thinking) problems that may be hard to notice early in life.

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The critical question is therefore: Is it reasonable to start all new CML patients on treatment with imatinib alone and continue the drug indefinitely in those who fare well, or should one start treatment with one of the newer agents or possibly with imatinib in combination with another anti-CML agent in order to secure the best possible outcome for an individual patient?

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PV is called a myeloproliferative disorder, which means that the bone marrow is producing too many cells too quickly.

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Researchers used bioengineering to create mice with a human gene that produces the defective hemoglobin causing sickle cell disease.

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However, the recovery from myelosuppression is rapid when therapy is interrupted.

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Effect of chronic red cell transfusion therapy on vasculopathies and silent infarcts in patients with sickle cell disease.

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This can result in anemia (a drop in the number of red blood cells) or neutropenia (a drop in the number of white blood cells).

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Hydroxyurea was originally developed as a cancer treatment.

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In other cases Gleevec decreases blood levels of the drugs which may decrease effectiveness of treatment.

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The partial pressure of the system also affects O 2 affinity where, at high partial pressures of oxygen (such as those present in the alveoli), the relaxed (high affinity, R) state is favoured.

Pregnant and nursing mothers should never take methotrexate because it increases the risk for severe, even fatal, birth defects and miscarriage.

These excess cells thicken your blood and cause complications, such as such as a risk of blood clots or bleeding.

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Nikolsky's sign seen in pemphigus group of disorders in which there is separation of epidermal layers on application of lateral pressure to normal appearing skin.

Today both agents are commonly used in combination with carboplatin or the 5-FU, hydroxyurea and concomitant radiotherapy (FHX) platform.

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TCD With Transfusions Changing to Hydroxyurea (TWiTCH) is a phase 3 multicenter randomized clinical trial for children with SCA and abnormal TCD velocities.

This phenomenon, where molecule Y affects the binding of molecule X to a transport molecule Z, is called a heterotropic effect.

Vaso-occlusion is also a vasculopathy involving endothelial cell dysfunction, leukocyte activation, platelet activation and chronic inflammation resulting in the multiple adhesive interactions between cellular elements.

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These results suggest that an important class of disease modifiers in sickle cell anemia affect the rate of hemolysis.

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Hydroxyurea is an antimetabolite that is used in the treatment of cancer and to stimulate fetal hemoglobin production in sickle cell disease.

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After gastric digestion and in the presence of disease the spleen enlarges.

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