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Why aminoglycosides are contraindicated in myasthenia gravis? Aminoglycoside antibiotics impair neuromuscular transmission and can cause clinically significant muscle weakness, resulting in respiratory depression in myasthenia patients. Gentamicin is therefore contraindicated in MG; amikacin, tobramycin, neomycin and streptomycin are also contraindicated.
What cell is attacked by the immune system in myasthenia gravis? In myasthenia gravis, they attack and damage muscle cells. The immune system normally defends the body against diseases, but sometimes it can turn against the body, leading to an autoimmune disease.
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