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Antibiotics: Macrolide antibiotics have been reported to cause a significant decrease in corticosteroid clearance (see Drug Interactions: Hepatic Enzyme Inducers, Inhibitors and Substrates).

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Compare the efficacy of high-dose dexamethasone vs conventional prednisone as a first-line strategy for newly diagnosed adult idiopathic thrombocytopenia, based on a prospective, multicenter, randomized trial.

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Similarly in patients with allergic rhinitis (hay fever) an intramuscular dose of 80 to 120 mg may be followed by relief of coryzal symptoms within six hours persisting for several days to three weeks.

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