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Age, time since menopause, body-mass index, presence or absence of vasomotor symptoms at base line, coronary-risk-factor status, and other variables were not significantly related to the risk of CHD with hormone therapy.

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The current treatment for women after hormone-sensitive breast cancer is estrogen-blocking aromatase inhibitors, a nearly opposite treatment to the hormone therapy we studied.

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Experimental and clinical evidence suggests that 16alpha-hydroxylated estrogen metabolites, biologically strong estrogens, are associated with breast cancer risk, while 2-hydroxylated metabolites, with lower estrogenic activity, are weakly related to this disease.

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