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DSM-IV schizophrenia (SCZ) patients for white matter abnormalities at baseline in comparison with healthy controls (HC) and the effect of 3-6 months of treatment with antipsychotic (AP) medications on white matter micro-structure.

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The mean baseline PANSS total and negative subscale scores, BPRSd total and core items scores, as well as the CGI-S scores, indicate that all three treatment groups had moderately severe levels of over-all psychopathology, positive symptoms, and negative symptoms ().

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In conducting the study, Rachael Taylor, a research associate professor in the department of human nutrition at the University of Otago in Dunedin, New Zealand, and colleagues followed 244 children from the age of 3 years to 7 years.

Methods: Childhood adversity (separation from parents, parental loss, physical and sexual abuse) was assessed retrospectively for 224 first-presentation psychosis cases and 256 community controls from South London, UK, using the Childhood Experience of Care and Abuse Questionnaire (CECA.

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One meta-analysis suggested that the addition of antidepressants to antipsychotics might help treat the negative symptoms of chronic schizophrenia, which can be difficult to distinguish from depression.

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