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Clinical examples of this balancing role of the endorphins, in concert with ACTH with which it shares that similar molecular configuration, were discussed above in the studies with Naloxone and Naltrexone where the subjective response was more one of calm and relaxation rather than a "high" (1, 11).

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At the point of giving consent, patients were informed that naltrexone had been shown in previous studies in alcoholism treatment centres to reduce craving for alcohol and alcohol consumption.

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