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When I first started taking Hydroxyurea it made me a little sick. Yet, after about 2 weeks I noticed a slight increase in energy and went from having a hospitalization crisis every 2-3 months to about ONCE a year. I still take pain meds for the smaller pains but my lifestyle had gotten MUCH better. I would recommend it to any person with sickle cell.



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The treatment may also slow the production of blood cells by your bone marrow.

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Data are prospectively gathered on hydroxyurea pharmacokinetics, genotoxicity, and long-term effects on organ function.

Sickling that blocks oxygen to the bone can also cause bone loss and pain.

Hydroxyurea is also used to reduce pain episodes and the need for blood transfusions in people with sickle cell anemia.

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NURSING DIAGNOSES Imbalanced nutrition: Less than bodyrequirements Deficient fluid volume Acute painTREATMENT TPN Restoration of fluid and electrolyte balanceDrug therapy Antiemetics, as necessary, for vomitingINTERVENTIONS AND RATIONALES Monitor vital signs and fluid intake andoutput to assess for fluid volume deficit.

Further attempts should not be made to titrate to a dosage level that resulted in hematologic toxicity during 2 separate periods of dosage adjustment.

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Treatment of Children With Anagrelide for Thrombocythemia.

Alternatively, youmay need to assessa client with arespiratory conditionfor depression orsuicidal thoughts.

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FINDINGS Change in color, size, or shape of preexisting lesion Irregular, circular bordered lesion withhues of tan, black, or blue (melanoma) Local pain Oozing, bleeding, crusting lesion Pruritus Small, red, nodular lesion that begins as anerythematous macule or plaque with indistinct margins (squamous cell carcinoma) Waxy nodule with telangiectasis (basal cellepithelioma)DIAGNOSTIC TEST RESULTS Skin biopsy shows cytology positive forcancer cells.

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Before a bone marrow transplant can be performed, the patient must undergo chemotherapy to completely destroy their own bone marrow.

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Hydroxyurea exerts bi-modal dose-dependent effects on erythropoiesis in human cultured erythroid cells via distinct pathways.

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This can cause painful episodes and permanent damage to the eyes, brain, heart, lungs, kidneys, liver, bones, and spleen.

Guideline on the management of acute chest syndrome in sickle cell disease.

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There is a huge unmet need for patients with myelofibrosis.

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NURSING DIAGNOSES Constipation Diarrhea Chronic painTREATMENT Dietary changes: avoidance of foods thattrigger symptoms; increased fiber intake Increasing fluid intake to at least eight 8-ozglasses per day Stress management Heat applicationDrug therapy Sedatives: alprazolam (Xanax), lorazepam(Ativan) Antiflatulent: simethicone Antispasmodic: propantheline Antidiarrheal: diphenoxylate with atropineCONTRIBUTING FACTORSDiverticular diseaseFamily historyIrritants (caffeine, alcohol)SmokingStressASSESSMENT FINDINGS Abdominal bloating Constipation, diarrhea, or both313419NCLEX-RN_Chap08.

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McArthur, using a three-drug regimen containing d4T as the only "d-drug" leads to about the same rate of PN as a three-drug regimen that excludes all "d-drugs" (about 8%).

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Ingestion of breast milk from an infectedmotherASSESSMENT FINDINGSAnorexia, weight loss, recurrent diarrheaCoughDisorientation, confusion, dementiaFatigue and weaknessFeverLymphadenopathyMalnutritionNight sweatsOpportunistic infectionsPallorPainShortness of breathSkin lesionsDIAGNOSTIC TEST RESULTS Blood chemistry shows increased transaminase, alkaline phosphatase, and gammaglobulin levels and a decreased albumin level.

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Feugier P, Van Hoof A, Sebban C, et al, Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d'Etudes des Lymphomes de l'Adulte.

Theseverity of signs and symptoms varies withthe degree of encephalopathy and cerebraledema: Stage 1: vomiting, lethargy, hepaticdysfunction Stage 2: hyperventilation, delirium, hyperactive reflexes, hepatic dysfunction Stage 3: coma, hyperventilation, decorticate rigidity, hepatic dysfunction Stage 4: deepening coma, decerebraterigidity, large fixed pupils, minimal hepaticdysfunction Stage 5: seizures, loss of deep tendonreflexes, flaccidity, respiratory arrest (death isusually a result of cerebral edema or cardiacarrest)DIAGNOSTIC TEST RESULTS Blood test results show elevated serumammonia levels; serum fatty acid and lactatelevels are also increased.

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