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These plates contained twofold serial dilutions of the antifungal drugs and two drug-free medium wells for sterility and growth controls.
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D0870 is excreted by nonrenal mechanisms, and its half-life in mice was estimated to be more than 10 times longer than that of fluconazole (50 and 4 h, respectively) ().
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Onychomycosis is caused by three types of fungi, called dermatophytes, yeasts, and nondermatophyte molds.
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Examples of regimens that have been evaluated for safety and efficacy in randomized trials include a three- and a four-pulse regimen with doses of 200 mg of itraconazole twice daily (), a three-pulse regimen only with 200 mg of itraconazole twice daily (), and a two-pulse regimen with 200 mg of itraconazole twice daily ().
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Amphotericin B has greater avidity for ergosterol-rich fungal cell membranes vs cholesterol-rich mammalian cell membranes; however, this specificity may be lost when the drug accumulates to high concentrations in organs such as the kidney, where the drug causes direct damage to distal tubular membranes.
Although a detailed discussion of drug interactions is beyond the scope of this review, several recent reviews have been published on this topic.
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