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I am a 45 year old female. It was a shock for me when the doctors diagnosed me with PBC about 3 years ago. Since that time I have had liver biopsies and blood tests for many times. Recently I started to notice that I am getting more tired and confused than before. My energy is gone. I asked my doctor to change the treatment and he put me on Ursodiol. I find it has helped me a lot. I do have some complications with my bowels but nothing too serious. I am pretty sure that it is Ursodiol that is to be in charge for all the improvement in my condition. Next week I am to undergo another series of tests, I believe they'll show I'm right.



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I was dx PBC-Stage 2 Feb 08 and started URSO. I was sent to Baylor a few weeks later and their tests indicated I had a negative AMA! They asked me to stop taking URSO to see if weight loss alone improves the condition. I was off URSO for 4 months and lost 25 lbs. My AMA count is higher now than ever, so I am going back on URSO this morning. It is very obvious to me that the URSO put my antibodies to sleep while I was on the drug. That is why my doctor put me back on it today.

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Researchers at Johns Hopkins University, reporting in the June 25 issue of the Journal of the American Medical Association, found that certain types of epigenetic marks change during a persons lifetime and the amount of change is similar among related people.

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