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Part of the controversy concerns the diagnostic criteria used for children and adolescents.
Results: Sexual and physical trauma correlated significantly with dissociation.
However, there were no significant benefits of cognitive remediation on non-verbal working memory and learning and speed of processing or functional outcome measures.
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Many patients with schizophrenia are less willing to complete treatment tasks that they do not find enjoyable.
Thus, to assess the clinical risk of proarrhythmias, the regulatory agencies must rely upon the surrogate marker, namely QTc prolongation provided it is adequately investigated and quantified during drug development.
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Olanzapine has been widely studied and is approved by the FDA and the European Medicaments Agency (EMEA) for maintenance treatment.
In contrast, during long-term treatment, 17.
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NMS frequently occurs shortly after the initiation of neuroleptic treatment.
Conclusion: Controlled and additional observational studies seem warranted to confirm our preliminary findings suggesting ziprasidone may be more effective in obese compared to nonobese patients with BD already receiving combination pharmacotherapy.
In the pharmaceutical composition according to the invention, polymer, polyacrylic acid (known as carbopol), was advantageously used.
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The themes in this domain identified positive program effects important to recovery: fostered emotional well-being, fostered skill development, enabled personal empowerment and fostered connection with others.
Guideline summary: Practice guideline for the treatment of patients with eating disorders.
Conclusion: Development of a fidelity scale can be an important tool for securing the quality of SEI treatment in Denmark and can be a part of an internationally accepted and common fidelity scale.
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Pregnancy: As with other types of diabetes, the causes of gestational diabetes are unkown.
The cardiovascular health of young people with severe mental illness: addressing an epidemic within an epidemic.
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All MCCB tests were administered except the MSCEIT.
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Similarly, 14 patients were participants in a ziprasidone weight loss study but were generally similar to the 68 nonparticipants with respect to demographics, baseline characteristics, and clinical outcomes, so that data for these groups were pooled throughout this report.
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We hope that a neuroprotective therapy will be found, which would stop PD from progressing and save the dopamine-making cells in the brain.
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Women should have their lithium levels closely monitored during pregnancy.
London: EMEA; Points to consider: The assessment of the potential for QT interval prolongation by non-cardiovascular medicinal products.
Local side effects associated with intramuscular ziprasidone (the active ingredient contained in Geodon) have frequently included pain at the injection site.
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Further research on LP and its relationship with negative symptoms and potential use for targeting negative symptoms will be discussed.
In the study, however, such movement side effects weren't widely seen with perphenazine.
An Australian study found that babies born to women on these medications are more likely to spend time in a neonatal intensive care unit (NICU) or to need specialized care after birth.
Genotyping for 31 SNPs in the EGF system was performed using Multiplex and Taqman assays.
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Interest has also focused on the various connections within the brain rather than on localization in a single part of the brain.
Couples and families who are coping with BD should be considered for family therapy either on an inpatient or outpatient basis.
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Methods: 41 first-episode schizophrenia-spectrum patients were recruited and underwent a structural Magnetic Resonance Imaging (MRI).
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Institutional review board approval was obtained at each site, and all participants provided written informed consent.
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Blood pressure should be monitored at regular intervals, particularly during dosage escalation or whenever dosage has been altered, and patients should be advised not to rise abruptly from a sitting or recumbent position.
Gagan Fervaha, Ofer Agid, Hiroyoshi Takeuchi, George Foussias, Jimmy Lee, Gary Remington.
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Haloperidol dose can be doubled each time up to 20 mg if prior dosing is inadequate for severe agitation.
The relevance of this is uncertain because of the small numbers of patients taking atypical antipsychotics.
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As additional results from CATIE are analyzed, disseminated, and put into context, the hope is that the cumulative findings will yield a more complete picture of the interaction between patient characteristics, medication, environment, and outcomes.
The individual may show a lack of interest in eating or may refuse food as a consequence of delusional beliefs.
Background: Learning potential (LP), or the ability to improve cognitive performance following instruction, has been of interest to schizophrenia researchers because it may be a predictor of rehabilitation response.
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Results: Despite increasing evidence that early episode schizophrenia patients show much better treatment response than those with chronic illness, and that these patients present a significant challenge with respect to adherence, the use of depots in this group of patients has hardly been contemplated and, consequently hardly studied.
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On December 1, 2008, announced that the FDA had accepted the company's ANDA to market its own version of sustained-release quetiapine.
These preliminary data suggest that exercise is a low risk, non-pharmacological means of producing clinical improvements in mood in first-episode schizophrenia patients.
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Conclusion: These results are novel as they suggest merging awareness of illness and the need for treatment into a single dimension, and separating the self-reflectiveness dimension of cognitive insight into two independent dimensions.
In the Netherlands more and more mental health clients live in residential areas, this may bring along the risk of an increase in stigmatisation.
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Conclusion: Significant proportions of the caregiver of schizophrenic patients were suffering from psychiatric disorders that did not get any psychiatric treatment.
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Here we aim to replicate and extend previous classification work in an independent sample first by using similar criteria to define these groups and then by determining the extent to which regionally distinct volumetric brain abnormalities are present in these subgroups.
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As support from caregivers and peers following early trauma has been found to be one of the strongest protective factors associated with resilience to other mental health outcomes, this study explored whether social support modifies the association between childhood trauma and psychosis.
The shared pharmacology of typical APDs is limited to D 2 receptor antagonism ( ) which predicts efficacy and mechanism-driven side effects such as EPS and plasma prolactin increases.
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Once your youngster's IEP is developed, a meeting is scheduled once a year to review your youngster's progress and to make any alterations to reflect his or her changing needs.
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It is not clear, however, if this correlation reflects a cumulative effect of psychotic outbursts with gradual progressive reduction of hippocampal tissue, or, rather, an increased tendency for psychotic episodes in patients with smaller hippocampus at the beginning of illness.
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The risk of weight gain, increased BMI and abnormal lipids appears greatest with olanzapine, followed by clozapine and quetiapine.
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Vector-based Spatial-temporal Analysis using L1-minimum-norm provided whole-brain maps of activity from 80-130ms (M100).
First-generation antipsychotics are more likely to cause movement disorders.
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All reported events are included except those already listed in Table 3 or elsewhere in labeling, those event terms that were so general as to be uninformative, events reported only once and that did not have a substantial probability of being acutely life-threatening, events that are part of the illness being treated or are otherwise common as background events, and events considered unlikely to be drug-related.
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This finding together with the normalization of striatal reward disturbance following treatment in non-improving patients suggests that striatal reward disturbance might not be related to the negative symptom domain.
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In this study we first explore the effect of cognitive remediation (CR) on two clusters of negative symptoms (i.
The specific symptom models found similar effects, although many did not have a significant effect for time.
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