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The complete function of PAU genes is unknown but research done by Martinez, Barre, and Blondin and Luo and van Vuuren makes predictions about the function based on data suggesting the regulation and expression of PAU genes.
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Selenium sulfide: This works in a fashion similar to coal tar in that it slows the rate of skin cell death and thus the accumulation of dead skin cells, but it doesn't have the odor or aesthetic issues of coal tar.
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It is postulated, but not proven, that the therapeutic effect of ketoconazole in tinea (pityriasis) versicolor is due to the reduction of Pityrosporum orbiculare ( Malassezia furfur) and that the therapeutic effect in dandruff is due to the reduction of Pityrosporum ovale.
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The primary objective of this study will be to determine the side effect profile of ketoconazole when combined with weekly docetaxel therapy and determine the maximum tolerated dose (MTD) and a recommended phase II dose (RPIID) of docetaxel when combined with high dose ketoconazole.
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If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Ketoconazole (Nizoral, Extina, Xolegel, Kuric) is an anti-fungal medication prescribed to treat fungal infections such as thrush, ringworm, jock itch, athlete's foot, dandruff, tinea versicolor, blastomycosis, histoplasmosis, and coccidiomycosis.
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Urine is entirely sterile after secretion and has an antiseptis effect.
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Other related drugs in this class include itraconazole, miconazole and fluconazole.
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Fungal Culture: Fungal cultures are incubated for 4 weeks.
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Although they are effective and cost significantly less than topical antifungals and calcineurin inhibitors, topical corticosteroids are best used as second-line agents because long-term use has been associated with thinning of the skin and formation of telangiectasia.
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Further, murine experiments have shown increased hair growth following the use of topical ketoconazole in a 95% ethanol solution, suggesting its potential benefit in the treatment of patterned hair loss.
Successful response rates in the primary efficacy population for each of both three-day and single-day regimens of Ketoconazole Shampoo, 2%, were statistically significantly greater (73% and 69%, respectively) than a placebo regimen (5%).
Transient increases in hepatic aminotransferases, cholestasis, and mixed hepatotoxic effects (reversible within months of drug cessation) have also been associated with ketoconazole.
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Use of a comedo extractor is recommended by the authors of Yu et al rather than a simple skin scraping for KOH preparation as this will reveal levels of yeast within the follicle rather than the stratum corneum.
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