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Should I take prednisone in AM or PM? But too often patients take prednisone between 6 a.m. and 8 a.m., says Dr. Cutolo, when it may come too late to curb the inflammation. "The best time, the optimal time, in chronic long-term treatment with low-dose glucocorticoids is availability at the time of maximum need, which is the middle of the night."

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