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The efficacy and safety of the antithyroid drug methimazole has been evaluated over a 3-year period in a study of 262 cats with hyperthyroidism (Peterson ME, Kintzer PP, Hurvitz AI, Methimazole Treatment of 262 Cats With Hyperthyroidism.

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He is showing some signs of possible hyperT effects (howling, increased drinking, restlessness), based on the signs I observed in him when he was first DX'd.

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Because of the risk for congenital malformations associated with use of methimazole in the first trimester of pregnancy it may be appropriate to use other agents in pregnant women requiring treatment for hyperthyroidism.


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Oral NAC, IV NAC, and IV sodium sulfate were evaluated as treatments for cats who had received toxic sublethal doses of acetaminophen (APAP).

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TSI causes the thyroid gland (located at the base of your neck) to produce too much of the thyroid hormones (T4) and (T3).

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So started around 9-10 years ago on methimazole, and TSH to this date goes up to normal, then they reduce the dose, and then TSH plummets; so up I go again on the dose.

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Therefore, low-dose effects could be observed at the lower end of a monotonic or linear dose-response curve.

Just like an endocrinologist, a natural endocrine doctor will look at your blood tests, symptoms, and case history.

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Once the thyroid hormone levels start falling into the low-normal range, it is reasonable to stop antithyroid medications and to consider starting low-dose thyroid hormone replacement before the patient becomes hypothyroid; however, some physicians prefer to document persistently elevated TSH values with the patient off antithyroid medication before starting thyroid hormone replacement.

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One solution that is common in Europe, but less so in the US is just staying on the anti-thyroid drugs permanently.

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